Delivering Protection Against Inflammatory Disease
LDPP is a novel, proprietary analog of muramyl dipeptide (“MDP”), a natural immunoactive compound of the bacterial cell wall. Like MDP, LDPP binds NOD2. MDP induces an initial burst of NF-kB-mediated inflammation. Remarkably, LDPP inhibits NF-kB.
The canonical ligand of NOD2 is muramyl dipeptide (MDP). For decades, MDP was viewed as a trigger for inflammation. NOD2 ligands are now known to deliver:
potent, IRF-4-mediated downregulation of inflammation on continual administration
antiviral Type I interferons and
enhanced phagocytosis.
LDPP Demonstrates Significant Survival Benefit Against Lethal Respiratory Disease
Strong treatment effect demonstrated in pigs, an animal model with high translational value, much more like humans than mice are.
